Biliary excretion in foreign compounds. Species difference in biliary excretion
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چکیده
منابع مشابه
Biliary excretion in foreign compounds. Species difference in biliary excretion.
1. The biliary excretion of injected [(14)C]aniline, [(14)C]benzoic acid, 4-amino-hippuric acid and 4-acetamidohippuric acid in six or eight species of animal (rat, dog, hen, cat, rabbit, guinea pig, rhesus monkey and sheep) was studied. 2. These compounds, with molecular weights in the range 93-236, are poorly excreted in the bile in all the species examined and, in effect, there is little sig...
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1. The extent of biliary excretion in the rat of 15 sulphonamide compounds was studied. 2. Most of the sulphonamides studied, with molecular weights from 172 (sulphanilamide) to 352 (N4-acetylsulphadimethoxine) are poorly excreted in the bile (0-4% of the dose), except sulphapyridine, sulphamethoxypyridazine and sulphadimethoxine. The last three are partly metabolized to glucuronides, whose mol...
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Biliary excretion of cadmium was studied in two groups of five rats which were given repeated injections of 109Cd. The first group was given a total amount of 6 mg Cd/kg which was 6 times as much as the second group. The elimination of cadmium in bile, urine, and feces was measured 4 to 5 weeks after the last injection. The relative biliary excretion of cadmium was the same in both groupetion, ...
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Introduction In these experiments, we assessed the role of hepatocyte lysosomes in biliary excretion of iron. We loaded rats with iron by feeding 2% carbonyl iron and collected bile for 24 h via bile fistulae from iron-loaded and control rats. In additional rats, bile was collected before and after the administration of colchicine. Rats were then killed and their livers were homogenized and fra...
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The biliary excretion of copper was measured in eight patients with Wilson's disease (three untreated, with hepatic dysfunction) and 10 control subjects (three with hepatic dysfunction). The duodenum was perfused with an amino-acid solution containing a non-absorbed marker, (51)CrCl(3), and juice was aspirated from the duodeno-jejunal junction. The mean concentration of copper in the duodenal a...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1967
ISSN: 0306-3283
DOI: 10.1042/bj1051289